2010 Schedule | ||||
| Week | Opponent | Game Information | Score | |
| 1 | vs. MIA | Lost | 10 - 15 | |
| 2 | @ GB | Lost | 7 - 34 | |
| 3 | @ NE | Lost | 30 - 38 | |
| 4 | vs. NYJ | Lost | 14 - 38 | |
| 5 | vs. JAC | Lost | 26 - 36 | |
| 6 | « BYE WEEK » | |||
| 7 | @ BAL | Lost | 34 - 37 | |
| 8 | @ KC | Lost | 10 - 13 | |
| 9 | vs. CHI | Lost | 19 - 22 | |
| 10 | vs. DET | Won | 14 - 12 | |
| 11 | @ CIN | Won | 49 - 31 | |
| 12 | vs. PIT | Lost | 16 - 19 | |
| 13 | @ MIN | Lost | 14 - 38 | |
| 14 | vs. CLE | Won | 13 - 6 | |
| 15 | @ MIA | Won | 17 - 14 | |
| 16 | vs. NE | Lost | 3 - 34 | |
| 17 | @ NYJ | Lost | 7 - 38 | |
Buffalo Bills
AFC East
(4 - 13)
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